REFLUDAN [lepirudin (rDNA) for injection]: the first direct thrombin inhibitor FDA-approved for heparin induced thrombocytopenia (HIT)

Learn more about the benefits of REFLUDAN
This section contains REFLUDAN laboratory and clinical efficacy data
This section contains information regarding the safe administration of REFLUDAN for the treatment of heparin induced thrombocytopenia (HIT)
This section describes the dosage and administration of REFLUDAN in the treatment of heparin induced thrombocytopenia (HIT)
This section describes how to dose and administer REFLUDAN for the treatment of heparin induced thrombocytopenia (HIT)
Dosing Calculator
This section describes the simple dose adjustments required when initiating REFLUDAN therapy in patients with renal impairment
This section describes the technique required for the reconstitution and dilution of REFLUDAN
This section describes the steps required to monitor and adjust REFLUDAN therapy
This section describes the technique required to make a safe transition from REFLUDAN to oral anticoagulation therapy
Heparin induced thrombocytopenia
A summary of pivotal trial data for REFLUDAN is covered in this section
This section provides access to a variety of resources to obtain in-depth information on heparin induced thrombocytopenia (HIT) and REFLUDAN
Find out what your peers are saying about heparin induced thrombocytopenia (HIT)...

©2007 Bayer Healthcare Pharmaceuticals Inc. All rights reserved.
H.I.T. BACK with REFLUDAN to protect life and limb
Dosing Calculator

Dosing Calculations for HIT Patients1



To calculate the REFLUDAN bolus dose and infusion rate for HIT patients without renal impairment, type in patient body weight (kg or lb). Administer the dose in the window next to the appropriate infusion bag size.

Dosing Calculations for HIT Patients with Renal Impairment1



To calculate the dose of REFLUDAN for HIT patients with renal impairment, type in patient body weight (kg or lb) and either the creatinine clearance or serum creatinine value. Administer the dose in the window next to the appropriate infusion bag size.

Download the REFLUDAN Dosing Calculator



Download the Dosing Calculator for your PDA or Desktop.



* In hemodialysis patients or in case of acute renal failure (CrCL <15 mL/min or SCr >6.0 mg/dL), infusion of REFLUDAN is to be avoided or stopped. Additional IV bolus doses of 0.1 mg/kg body weight should be considered every other day only if the aPTT ratio falls below the lower therapeutic limit of 1.5.



Dosage and Administration
Dosing Calculator
Patients with Renal Impairment
Reconstitution and Dilution
Monitoring and Adjusting REFLUDAN Therapy
A Straight Forward Transition to Oral Anticoagulation
Terms of Use      Privacy Policy      About Our New Company
Bayer Healthcare Pharmaceuticals