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Reconstitution and further dilution are always carried out under sterile conditions.
Bolus dose
CAUTION:Preparation of REFLUDAN bolus injection requires dilution following reconstitution in order to obtain the final concentration of 5mg/mL
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Use one 50-mg vial of REFLUDAN |
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Inject 1-mL Sterile Water for Injection USP or 0.9% Sodium Chloride Injection USP into vial; shake gently to obtain clear, colorless solution |
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Transfer vial contents to sterile disposable syringe with >10 mL capacity |
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Dilute solution to a total volume of 10 mL using Sterile Water for Injection USP, 0.9% Sodium Chloride USP, or 5% Dextrose Injection for a final concentration of 5 mg/mL |
Continuous infusion
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Use two 50-mg vials of REFLUDAN |
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Inject 1-mL Sterile Water for Injection USP or 0.9% Sodium Chloride Injection USP into each vial; shake gently to obtain clear, colorless solution |
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Transfer contents of both vials into 1 infusion bag containing 500 mL or 250 mL of either 0.9% Sodium Chloride Injection USP or 5% Dextrose Injection |
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Final concentration of 500-mL bag is 0.2 mg/mL |
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Final concentration of 250-mL bag is 0.4 mg/mL |
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Determine appropriate infusion rate according to REFLUDAN concentration, patient weight, and creatinine clearance using the Dosing Calculator |
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Additional notes
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The reconstituted solution is to be used immediately; REFLUDAN is stable for 24 hours at room temperature (eg, during infusion) |
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REFLUDAN should not be mixed with other drugs except for Sterile Water for Injection USP, 0.9% Sodium Chloride Injection USP or 5% Dextrose Injection |
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Sterile conditions must be maintained during reconstitution and dilution |
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