Bolus = 0.2 mg/kg body weight

Infusion rate adjustments in patients with renal impairment           Adjusted infusion rate       Creatinine   clearance   (mL/min)       Serum   creatinine   (mg/dL)       % of standard   initial infusion   rate       (mg/kg/h)       45-60       1.6-2.0       50%       0.075       30-44       2.1-3.0       30%       0.045       15-29       3.1-6.0       15%       0.0225       Below 15*       Above 6.0*       Avoid or stop infusion*

To calculate appropriate dose, please use the REFLUDAN Dosing Calculator.



* In hemodialysis patients or in case of acute renal failure (creatinine clearance below 15 mL/min or serum creatinine above 6.0 mg/dL), infusion of REFLUDAN is to be avoided or stopped. Additional IV bolus doses of 0.1 mg/kg body weight should be considered every other day only if the aPTT ratio falls below the lower therapeutic limit of 1.5.

Dosage and Administration Dosing Calculator Patients with Renal Impairment Reconstitution and Dilution Monitoring and Adjusting REFLUDAN Therapy A Straight Forward Transition to Oral Anticoagulation