Determine patient's aPTT ratio: To avoid initial overdosing, do not start REFLUDAN if aPTT ratio is >2.5
	Assess renal function: Determine baseline creatinine clearance or serum creatinine
	REFLUDAN is dosed by weight up to 110 kg; patients >110 kg receive 110-kg dosage

	IV bolus: 0.4 mg/kg
	—  Administer bolus dose intravenously over 15 to 20 seconds —  Immediately following administration of bolus dose, begin REFLUDAN infusion —  CAUTION: Preparation of REFLUDAN bolus injection requires dilution following reconstitution in order to obtain the final concentration of 5mg/mL
	Continuous IV infusion: 0.15 mg/kg/hour, as long as clinically needed
	—  Duration of therapy is generally 2 to 10 days
	Simple dose adjustments when initiating therapy in patients with renal impairment

To calculate appropriate dose, please use the REFLUDAN Dosing Calculator.

Initial bolus dose provides rapid attainment of therapeutic levels (10 minutes)

Dosage and Administration Dosing Calculator Patients with Renal Impairment Reconstitution and Dilution Monitoring and Adjusting REFLUDAN Therapy A Straight Forward Transition to Oral Anticoagulation