REFLUDAN [lepirudin (rDNA) for injection]: the first direct thrombin inhibitor FDA-approved for heparin induced thrombocytopenia (HIT)

Learn more about the benefits of REFLUDAN
This section contains REFLUDAN laboratory and clinical efficacy data
This section contains efficacy data from principal clinical trials and a drug monitoring program of REFLUDAN for the treatment of heparin induced thrombocytopenia (HIT)
This section contains data from a prospective, historically-controlled trial to evaluate the anticoagulant efficacy of REFLUDAN in patients with confirmed heparin induced thrombocytopenia (HIT)
This section describes the combined risk of death, limb amputation, or new thromboembolic complication (TEC) in patients treated with REFLUDAN for heparin induced thrombocytopenia (HIT)
This section contains information regarding the safe administration of REFLUDAN for the treatment of heparin induced thrombocytopenia (HIT)
This section describes the dosage and administration of REFLUDAN in the treatment of heparin induced thrombocytopenia (HIT)
Heparin induced thrombocytopenia
A summary of pivotal trial data for REFLUDAN is covered in this section
This section provides access to a variety of resources to obtain in-depth information on heparin induced thrombocytopenia (HIT) and REFLUDAN
Find out what your peers are saying about heparin induced thrombocytopenia (HIT)...

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H.I.T. BACK with REFLUDAN to protect life and limb
References
1.  REFLUDAN® [lepirudin (rDNA) for injection] Prescribing Information.
2.  Greinacher A, Eichler P, Lubenow N, Kwasny H, Luz M. Heparin-induced thrombocytopenia with thromboembolic complications: meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range. Blood. 2000;96:846-851.
3.  Lubenow N, Eichler P, Greinacher A. Results of a large drug-monitoring program confirm the safety and efficacy of lepirudin in patients with immune-mediated heparin induced thrombocytopenia (HIT). American Society of Hematology 2002 Annual Meeting Abstracts. Blood. 100 (11) Abstract.
4.  Greinacher A, Völpel H, Janssens U, et al, for the HIT Investigators Group. Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia: a prospective study. Circulation. 1999;99:73-80. (HAT-1)


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