REFLUDAN [lepirudin (rDNA) for injection]: the first direct thrombin inhibitor FDA-approved for heparin induced thrombocytopenia (HIT)

Learn more about the benefits of REFLUDAN
This section contains REFLUDAN laboratory and clinical efficacy data
This section contains information regarding the safe administration of REFLUDAN for the treatment of heparin induced thrombocytopenia (HIT)
This section describes the dosage and administration of REFLUDAN in the treatment of heparin induced thrombocytopenia (HIT)
Heparin induced thrombocytopenia
This section describes the clinical use of heparin and its role in the development of heparin induced thrombocytopenia (HIT)
This section describes the clinical consequences of heparin induced thrombocytopenia (HIT)
This section lists the most frequent thromboembolic complications (TECs) that can develop in patients with heparin induced thrombocytopenia (HIT)
This section includes the severe consequences of heparin induced thrombocytopenia (HIT) and underscores the importance of prompt diagnosis and treatment of patients when HIT is suspected
This section lists the average direct medical charges associated with some of the individual thromboembolic complications (TECs) that may occur in patients with heparin induced thrombocytopenia (HIT)
This section describes the signs of heparin induced thrombocytopenia (HIT) and the timeframe in which they generally occur
This section emphasizes the need for platelet count monitoring in all patients receiving heparin to assist in the identification of patients who develop heparin induced thrombocytopenia (HIT)
This section describes the signs, symptoms, and management of heparin induced thrombocytopenia (HIT)
This section describes the laboratory tests that can be used to confirm heparin induced thrombocytopenia (HIT)
A summary of pivotal trial data for REFLUDAN is covered in this section
This section provides access to a variety of resources to obtain in-depth information on heparin induced thrombocytopenia (HIT) and REFLUDAN
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Economic Consequences of HIT-Associated TECs
These data represent average direct medical charges per discharge associated with some of the individual TECs that may occur in patients with HIT.10 The occurrence of any of these complications can be expected to add significantly to the cost of a hospital stay.

Direct costs of TEC-associated events10

 
 Type of Event/Complication 
 		  
 Average Total 
 Charge/Discharge 
 
 
 Venous thrombosis 
 Deep vein thrombosis 
 Pulmonary embolism 
 		  
 
 $8,017 
 $14,676 
 
 
 Arterial thrombosis 
 Myocardial infarction with CV 
 complications, discharged alive 
 		  
 
 
 $17,326 
 
 
 Amputation 
 Upper limb and toe 
 Other amputation for 
 circulatory system disorders 
 		  
 
 $18,573 
 $31,131 
 
 



Heparin-Induced Thrombocytopenia (HIT)
Heparin Use
Clinical Consequences of HIT
Thromboembolic Complications (TECs)
Iceberg Model of HIT
Economic Consequences of HIT-Associated TECs
When to Suspect HIT Type 2
Vigilant Monitoring is Critical
General Diagnosis and Treatment Algorithm for HIT
Laboratory confirmation of diagnosis
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